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Only six companies received multiple approvals: four for Pfizer and two each for Array, AstraZeneca, Lilly, Shionogi, and Shire
Titus AS, Sung E-A, Zablocki D, Sadoshima J (2023) Mitophagy for cardioprotection
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the first step is conjugation of glutamic acid and cysteine, which is catalyzed by glutamate-cysteine ligase and generates -glutamyl-cysteine (-Glu-Cys) and the second step is catalyzed by glutathione synthase, which adds glycine to -Glu-Cys, forming glutathione
