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Luteolin suppresses this pathway by preventing phosphorylation and degradation of the inhibitory protein IB, thereby blocking nuclear translocation of NF-B p65 and reducing transcription of pro-inflammatory cytokines (TNF-, IL-1, IL-6), iNOS, COX-2, and adhesion molecules (Khan et al., 2024)

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While the exact incidence of phototoxic reactions is unknown, clinicians should be aware of the relative abundance of such reactions, particularly as outdoor leisure activities increase and as the long-term correlation for cutaneous tumor development continues to rise [228]

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Repeat up to 3 times weekly

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