glutathione synthetase deficiency prevalence Frontiers The importance of glutathione in
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These free radicals are very unstable but highly reactive and, when they interact with other molecules, create additional free radicals, initiating a self-propagating chain reaction of free radical formation [18]

Furthermore, the construction of a regulatory network in the high cuproptosis-OXPHOS group identified high-mobility group A1 (HMGA1) as a critical transcription factor that modulates cuproptosis, offering new insights into targeted therapeutic strategies [62]

Monascin and ankaflavin act as natural AMPK activators with PPAR agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice