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The level of TMAO in each stage of CKD patients was different (Hu et al., 2022)
TMAO can combine with and trigger the ER stress kinase PERK, specifically stimulating the PERK arm of the unfolded protein response (UPR)
Finally, emerging studies have begun to investigate whether specific miRNAs or epigenetic modulators could regulate key enzymes and inflammatory pathways involved in TMAO metabolism [32, 33], although this remains largely experimental
Circ Heart Fail
