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While overexpression of EGFP-p62 led to a strong accumulation of p62-positive bodies in the cytosol compared to the control cells overexpressing EGFP only, there was no increase in colocalization with TOMM20 (Fig

PRDX3 and PRDX4 scavenge ROS within the mitochondria and ER, respectively, while PRDX5 and PRDX6 localize to multiple cellular compartments ( Additional detoxification systems include the thioredoxin (TRX1/2) pathway, which is particularly important for neutralizing ROS generated during disulfide bond formation in the ER, and superoxide dismutase 2 (SOD2), which catalyzes the conversion of superoxide into hydrogen peroxide (31, 32)

A., Jensen, T

One critical organ for blood pressure regulation is the kidney, which is highly sensitive to zinc deficiency