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Intramuscular injections may feel slightly more noticeable since the needle goes deeper into the muscle, but using proper technique and following your providers instructions can make the process more comfortable

Typical responses are localized irritation at injection sites, mild allergies, and brief flu-like symptoms
doi: 10.1016/j.brainres.2006.07.108

Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis
