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Precautions Do not use in patients with a known allergy or previous hypersensitivity reaction to any ingredients, active inflammation of a superficial vein, significant dysfunction of vein valves or deep vein insufficiency, large superficial veins that connect to deeper veins, a history of migratory phlebitis, or an active skin and soft tissue infection, such as cellulitis

Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor gamma coactivator 1alpha

It does not precipitate at refrigerator temperatures and remains active throughout the 28-day post-opening period

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