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No se dispone en las fuentes abiertas de un valor bien establecido de vida media plasmtica humana para el GSH nativo

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For example, recent studies showed a relationship between rs12201199 in thiopurine S-methyltransferase gene ( TPMT ) and rs9332377 in the catechol-O-methyltransferase gene ( COMPT ) with cisplatin-induced hearing loss in children (Ross et al., Finally, prospective clinical studies employing polymorphism panels in these treatment procedures are required to determine whether adjustment of therapy based on genetic information can influence outcomes in these scenarios

Research has also indicated that vitamin C treatment increases hydroxymethylation in lymphoma and melanoma cells, and causes a decrease in tumor-cell invasiveness and clonogenic growth (Shenoy et al., 2017)