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Presence, activity and properties of glutaredoxins are often analysed in coupled spectrophotometric reductive assays with bis(2-hydroxyethyl)disulfide (HEDS) as a non-glutathione substrate 10,11,12,15,16,17,18 or L-cysteine-glutathione disulfide (GSSCys) as a glutathionylated substrate 10,11,12,18,19,20,21 (Fig

For them it is often deemed to be a comfort treatment or plastic surgery procedure that has nothing to do with their very job besides the fact that there is no real scientific background

119 MaesM.MihaylovaI.KuberaM.UytterhoevenM.VrydagsN.BosmansE

Together, these results reveal mechanistic details of the SBS-PolkKO mutations and underscore the fact that mutational signatures are complex patterns jointly shaped by the nature of the DNA lesion and the interplay of DNA repair and lesion bypass processes