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In the Purkinje cell layer, the mean number of dark neurons significantly increased in the CN group (2.465 0.135/10 m 2 ) in comparison with the VC group (P = 0.0049, Figures 4C, D, I)

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This study, the CARES trial, looked at 5000 patients, all of whom had some cardiovascular disease history, either heart attack, stroke, min-stroke or need for urgent heart surgery for coronary disease