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A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease

Furthermore, in contrast to neurons, astrocytes are equipped with a plentiful reservoir of antioxidants, enabling them to effectively mitigate the oxidative stress induced by the -oxidation of FAs [141, 161,162,163]

Abstract A growing number of metabolomic studies have associated high circulating levels of the amphiphilic fatty acid metabolites, long-chain acylcarnitines (LCACs), with cardiovascular disease (CVD) risk

Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A, Couture P, Dufour R, Fodor G, Francis GA, Grover S, Gupta M, Hegele RA, Lau DC, Leiter L, Lewis GF, Lonn E, Mancini GB, Ng D, Pearson GJ, Sniderman A, Stone JA, Ur E