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298,311 Over-activation of glutamate-sensitive receptors in the brain can further degrade blood-brain barrier function and trigger excitotoxicity, neuroinflammation, increased oxidative stress, protein aggregation, mitochondrial dysfunction, and nerve cell death, and is considered a possible contributor to cognitive disorders, depression, reduced neuroplasticity, and neurodegenerative diseases like Alzheimer disease, Parkinson disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), and Huntington disease

The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus

Couple counseling and psychosexual therapy have shown significant improvements in relationship satisfaction, addressing both sexual and relational conflicts [79,80]