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The selective mechanism that avoids systemic hormonal disruption suggests potential for extended use compared to interventions that create metabolic or endocrine imbalances requiring periodic breaks
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GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 auto-reactive CD4 T cells

References: Buxton ILO (2006): Pharmacokinetics and pharmacodynamics: the dynamics of drug absorption, distribution, action, and elimination
