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Members of the TGF- superfamily (TGF-1/2/3, GDF-5, and GDF-6) can all promote MSC differentiation towards NP-like cells, with GDF-6 having a particularly significant effect, inducing richer proteoglycan ECM synthesis, and showing more pronounced effects in AD-MSCs compared to BMSCs (Stoyanov et al., 2011

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Furthermore, through cell-based therapy such as fibroblasts and/or keratinocyte cells alone or in combination with membrane and skin grafts, wound healing accelerates 23