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Advanced glycation endproducts in diabetes and diabetic complications

Furthermore, A is able to promote the hyperphosphorlyation of Tau in both the cytosolic and synaptic compartments, which has been suggested as a potential explanation of the prion-like seeding hypothesis of Tau transmission inter-neuronally, accounting for the phosphorylated Tau detected in the CSF of AD patients (Wu et al., 2018

The metabolites showed much lower toxicity compared to the parent compounds [423]

[DOI] [PMC free article] [PubMed] [Google Scholar] 137.Camarda R., Zhou A.Y., Kohnz R.A., Balakrishnan S., Mahieu C., Anderton B., Eyob H., Kajimura S., Tward A., Krings G., et al