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Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury by reducing oxidative stress, HMGB1 expression, and inflammatory reaction

Survival analysis further revealed that the Psa-AR group achieved a median survival of 46 days, which was significantly longer than that of the PBS control (21 days), enzalutamide (27 days), pimitespib (29 days), and combination groups (31 days) (Fig

[ 264 , 265 ] Free ferrous iron (Fe 2+ ) catalyzes the conversion of hydrogen peroxide to hydroxyl radicals, thereby stimulating lipid peroxidation within cellular and organelle membranes