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This bidirectional link fuels its reputation as an "exercise-mimetic." To be explicit about evidence quality: the animal data is comparatively strong, but the human evidence is limited and correlational
Together, our findings reveal the mechanism of CDK4/6i resistance and provide a strategy for overcoming CDK4/6i resistance via METTL14 inhibition
Even though these results are intriguing, they are still preliminary, and more translational study is necessary before firm conclusions can be drawn
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