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Studies have demonstrated positive results of MT in various disease models, including central nervous system diseases [351], CVDs [352], inflammatory diseases [353], cancer [354, 355], and renal and lung injuries [20, 356]

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Future studies should prioritize (1) validating these findings in additional ALS models (e.g., TDP-43 or C9orf72-related models), (2) elucidating gut-brain axis interactions, and (3) assessing bioavailability and dosing regimens for clinical translation (Table 2)

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