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The absence of OCTN3 in humans, together with the OCT1 functional difference between humans and rodents, is a critical issue that limits the use of mice as a model
G., Carpeggiani, C., and Maseri, A
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In contrast, a decrease in LDL-C of 39mg/dL over 4-5 years with statin therapy results in only a 22% decrease in ASCVD events (27,28)
