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In the case of glucocorticoids, both excess (Cushings syndrome) and insufficiency (Addisons disease) contribute to oxidative stress through a variety of mechanisms, such as decreased antioxidant defenses, increased reactive oxygen species (ROS) generation, and impaired mitochondrial function, which ultimately results in chronic inflammation

This loss of membrane integrity can significantly impair sperm function, reducing motility, compromising the acrosome reaction, and hindering the sperms ability to bind effectively with the oocyte during fertilization

This creates a mini-fasted state that partially preserves bioavailability

in total, 9 genera (including the unclassified group) and 38 metabolites met these criteria (metabolites published in Sampson et al., 2021 13 )