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Acknowledgments This work was supported in part by the Japan Study Group of NAFLD (JSG-NAFLD, Kyoto, Japan)

Resistance against commonly used drugs is also being reported making the treatment quite challenging

Vitamin D, which is fat-soluble and a steroid hormone, is found in fish and mushrooms [71]

In this form the sulfate of P-APS is reduced to sulfite by the free thiol (reduced) group of Sulfur Assimilation The reduced sulfur is finally transferred from the carrier to O-acetylserine (OAS) forming cysteine : O-acetylserine + H2S (or carrier-S-S-) cysteine + acetate The OAS is formed from serine and acetyl-CoA: serine + acetyl-CoA O-acetylserine + CoA This whole process is illustrated as follows: This is summarized in Fig