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doi: 10.1016/j.bcp.2014.01.008 108

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In the LRP6-centric view, as constitutively activated forms of LRP6 fully activate -catenin signaling in an apparently Fz and Dvl-independent manner (He et al., 2004), LRP6 represents the key output whereas Fz and Dvl act upstream to control LRP6 activation

Polyphenols and inflammatory bowel disease: natural products with therapeutic effects
