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They synthesized a 5-fluorouracil acetic acid (5-FuA) prodrug responsive to endogenous stimuli (MMP2, MMP9, and ROS)

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This may be due to the fact that Mn 2+ ions are smaller and more tightly bound to polyP, making it easier to be wrapped in the cluster, while RER peptides are larger and have weaker interactions with polyP and can be dispersedly distributed in the area closer to the surface of the cluster (see details in Supplementary Figs