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These factors induce oxidative stress, endoplasmic reticulum (ER) stress, or DAMPs release, resulting in inflammation, immune dysregulation, and melanocyte destruction ( NLRP1 and IFIH , may predispose individuals to activate innate immune pathways more readily

When combined with liver malignancies, cirrhosis accounts for 3.5% of all deaths worldwide (Asrani et al., 2019)

Furthermore, mangoes are the source of a compound known as mangiferin, which early studies suggest may be able to reduce inflammation of the heart

[DOI] [PubMed] [Google Scholar] Noctor G, Mhamdi A, Chaouch S, Han Y, Neukermans J, Marquez-Garcia B, Queval G, Foyer CH