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B12 supplementation is appropriate for individuals with confirmed deficiency, vegans, older adults, those with malabsorption disorders, people who have had bariatric surgery, and those on long-term medications such as metformin or proton pump inhibitors

This suggests that B12 deficiency has detrimental effects on immune function and myelin production at younger ages [127]

The maternal microbiome undergoes significant changes throughout pregnancy, with notable enrichment of Proteobacteria and Actinobacteria, as well as overall lower richness toward the third trimester [21, 22]

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