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Sharabi A, Cohen E, Sulkes J, Garty M (2003) Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route

Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

This regulatory status reflects the absence of completed human clinical trials establishing safety and efficacy to approval standards

This enzyme is called tyrosinase