oxygen dependent intracellular killing ros production glutathione Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive species via depletion Cellular ROS and Antioxidants: Physiological

Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival

In vitro experiments confirmed that A 25-35 treatment significantly inhibited the activation of the NRF2/SLC7A11/GPX4 signaling pathway in HT22 cells, upregulated the expression of Fe 2+ , TFR1, ACSL4, MDA, and GSSG, and decreased the expression of FTH1, SOD, and GSH, as well as the GSH/GSSG ratio, resulting in dysregulated neuronal iron metabolism, impaired amino acid antioxidant systems, mitochondrial dysfunction, and ferroptosis, which ultimately promoted neuronal injury

Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance

KRAS mutant protein and HMGB1 synergistically induce macrophage polarization to M1 type through the STING pathway, enhancing antitumor immunity (187)