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promises and prospects for human trials

The significance of Smad5 to the regulation of insulin processing and secretion was demonstrated in mice in which the Smad5 gene was knocked out

Resveratrol increases SHBG levels in human SHBG/humanized CAR double transgenic mice Based on our findings in HepG2 cells that hCAR mediates an increase in human SHBG production in response to resveratrol treatment, while mCAR does not, we generated a double transgenic mouse line by crossing humanized SHBG and CAR transgenic mice, and treated these animals ad libitum for 20 days with resveratrol (60 g/ml), CITCO (60 g/ml) or vehicle (ethanol at 0.001%) in the drinking water

The intervention was declared safe and feasible if: (1) no more than one of the six participants withdrew due to experiencing an adverse event attributable to treatment, and (2) at least four of the six participants were able to complete at least 75% of the prescribed dose of treatment and comply with study requirements