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Vascular (endothelial) dysfunction and tobacco cigarette smoking in epidemiological/observational studies Large-scale epidemiological studies have demonstrated that cigarette smoking is associated with vascular (endothelial) dysfunction

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Those that can be improved or treated are: Cigarette smoking and exposure to secondhand smoke Diabetes Being overweight or obese High cholesterol Physical inactivity Unhealthy diet (high in sodium, low in potassium, and drinking too much alcohol) Factors that cant be changed or are difficult to control: Family history of high blood pressure Race/ethnicity Increasing age Gender Chronic kidney disease Obstructive sleep apnea Socioeconomic status and psychosocial stress may also contribute to high blood pressure