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4 Concluding remarks, place in therapy, and future perspective Tirzepatide is a novel agent that is approved for the treatment of type 2 diabetes and will likely be approved for weight loss

s network meta-analysis, including 85,701 patients with type 2 diabetes enrolled in 36 RCTs, found no difference in the protective effect on AF between GLP-1RA and SGLT2i (RR=0.95 [95% CI: 0.76 to 1.20]), consistent with our study

Secondarily, the effect on gut microbiota composition, hepatic and renal function and hormones involved in appetite control were also assessed, as well as the possible interactions between the basal levels of these biomarkers and the observed effects of MO supplementation on glucose control