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On the other hand, addiction itself alters brain chemistry and behavior, making it harder to quit even when the negative consequences become clear

This journey has not been a straightforward path, but a winding road filled with potholes of relapse and detours of temptation

Smoking cessation interventions should highlight these differences and address co-use to effectively help people cope with triggers to smoke. The authors noted some limitations in the study, including their focus on the enhancement of perceived pleasure of smoking cigarettes by alcohol or marijuana rather than the ability of cigarettes to enhance the pleasurable effects of other substances. The other UCSF co-authors are Oona A

Iftekhar Uddin, MD, MSPH