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Dula also significantly reduced the expression of transforming growth factor-1 (TGF-1), phosphatidylinositol-3-kinase (PI3K), protein kinase B (AKT) signaling pathway, and the inflammatory cytokines: nuclear factor kappa B (NF-B), interleukin-6 (IL-6), and interferon- (IFN-) in colonic cellular structures
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2 GLP-1R monotherapy (e.g., semaglutide) is highly effective, but dual GLP-1R/GIPR agonists (e.g.,
