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This is a significant advantage for a medication often used in populations where kidney disease is common, such as those with type 2 diabetes
Van Itallie CM, Anderson JM
doi:10.1016/j.gastre.2021.06.002
A rapid dissociation rate is also required to allow ligands to leave the receptor timeously after activation, to avoid internalization and ultimately maintain the quantity of the incretin receptors in the body
