sarcopenia semaglutide A Multidisciplinary Perspective on Treatment and Medical Nutrition Therapy in Obesity Management | Current Obesity Reports GLP-1 Receptor Agonists for Obesity

Gastrointestinal effects Nausea is the most common side effect, affecting roughly 41% of participants in the REDEFINE 1 trial

Notably, participants consumed inadequate calories from carbohydrates, adequate calories from protein as a percentage of total calories (though critically insufficient in g/kg/day for muscle preservation), and excess calories from fat

It slows gastric emptying, which is the primary mechanism behind appetite suppression and also the primary cause of GI side effects

Semaglutide and tirzepatide are typically recommended along with lifestyle changes, such as a reduced-calorie diet and increased physical activity