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Essentially, semaglutide helps you feel full longer and reduces your appetite by mimicking a hormone in your body that controls hunger

It is also not recommended for use in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, as semaglutide may increase the risk of these conditions

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Comparators, estimands, and why the design matters The most scientifically valuable design would include not just a placebo arm but a semaglutide-monotherapy arm, because the central open question is whether adding cagrilintide improves liver outcomes beyond what semaglutide already achieves
