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Following acylation, acyl-proghrelin is transported to the Golgi apparatus, where prohormone convertase 1/3 (PC1/3) or PC2 cleave proghrelin to release mature ghrelin [34, 37]
Exenatide administered once weekly as opposed to twice daily was found to lower HbA1c more significantly in the DURATION- 1 and DURATION- 5 trials ( 1.9% vs
