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Direct recommendation: skip GoodRx unless you are locked into pens, the $25 card needs commercial insurance, and PAP is a genuine zero-cost path but only for Ozempic and only under 200% FPL

Cosmos Study December 5, 2024 Dual-Team Study Team A:Kersten Bartelt, RNGregory Edwards, PhD Team B:Christopher Alban, MDEric Barkley Key Findings Patients with diabetes who are prescribed semaglutide, exenatide, liraglutide, or dulaglutide experience a 2344% reduced likelihood of dementia compared to those prescribed other diabetes management medications

Also showed significant reductions in liver fat (up to 82.4%) and improvements in metabolic parameters Phase 3 (TRIUMPH-4) : The Phase 3 TRIUMPH-4 trial confirmed and exceeded Phase 2 results, demonstrating 28.7% mean weight loss at 68 weeks with the 12 mg dose -- the highest reported for any metabolic peptide in a Phase 3 trial Phase 3 program : Additional Phase 3 trials ongoing for obesity (TRIUMPH-1) and type 2 diabetes (TRANSCEND) MASLD/MASH : Specific trials underway evaluating liver-related endpoints Phase 3 TRIUMPH-4 data have confirmed the Phase 2 promise, though the full Phase 3 program across all indications is still ongoing

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