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The combined effects significantly improve glycemic control, weight management, and islet function, overcoming the limitations of conventional GLP-1RAs with single-target activity [10,18] (Figure 1)

In contrast, native endogenous glucagon-like peptide-1 (GLP-1), extracted from human and porcine gut on the basis of reactivity with antibodies, turned out to be potently insulinotropic in a perfused pancreas preparation [28]

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