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Unfortunately, this synergy is lost in prolonged hyperglycaemic states due to selective dysfunction in GIP signallingdownregulation of GIPR mRNA and accelerated receptor degradationwhereas sensitivity to GLP-1 remains intact [22, 23]

When youre losing 1-2+ kg per week on these peptides, youre rapidly shedding that protective layer

In the analysis of different types of GLP-1 receptor agonists, we found that liraglutide and dulaglutide were significantly associated with an increased risk of overall thyroid disorders