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Given the minimum TTO taken as 1, improper handling of TTO=0 cases in calculations may explain this deviation, and the same issue can also be noted in other tirzepatide studies.15,39 Moreover, a report that added 0.5 to all samples before inputting them into the calculation also showed inaccuracies.40 Since the proportion of TTO=0 data in the database is not negligibleaccounting for approximately 30% in this studythe innovative value reassignment method for TTO=0 data proposed herein showed greater rationality and rigor and enhanced analytical reliability

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Ringhalexin from Hemachatus haemachatus: a novel inhibitor of extrinsic tenase complex