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However, their mechanism of action presents unique physiological hurdles that can derail athletic performance if not managed correctly.[2][3] The Mechanism: Why It Matters for Sport GLP-1 agonists work primarily by mimicking a hormone that targets areas of the brain that regulate appetite and food intake

9,12-15 A systematic review and meta-analysis of randomised controlled trials evaluating weight reduction diets, with or without exercise, reported an 18% reduction in all-cause mortality over a median follow up of two years in adults with obesity

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Challa and colleagues showed that increased concentrations of GLP-1 or its analogue liraglutide stimulated 3T3-L1 pre-adipocyte differentiation in vitro , and injection of 100 g/kg liraglutide twice daily for 17 days in mice fed a high fat diet for 6 weeks increased adipogenesis as compared with vehicle-treated mice [75]