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Myostatin neutralization results in preservation of muscle mass and strength in preclinical models of tumor-induced muscle wasting

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By preventing ligand-induced activation of these receptors, bimagrumab promotes skeletal muscle hypertrophy by sparing myosin heavy chain from proteolytic degradation through inhibition of Smad2/3 phosphorylation [125], via a mechanism that is independent of the AKT/mTOR signaling pathway [126]

This lower concentration means larger injection volumes for the same dose, which can be an advantage for people who want more precise measurements at lower doses