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doi: 10.1056/NEJMoa1812389 9 MosenzonOWiviottSDCahnARozenbergAYanuvIGoodrichELet al
MEDI0832 (now known as cotadutide) is a balanced co-agonist based on the peptide sequence of glucagon, modified at specific amino acid positions in addition to a palmitic fatty acid side chain to prolong activity
They are a tool with a defined cost-benefit envelope that is now well characterized in the peer-reviewed literature
Phentermine typically results in an average weight loss of about 4.4% of body weight over 28 weeks, although some healthcare providers may not prescribe it for that long
