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Patients with MASLD who have not yet developed cirrhosis represent an important population for observational studies to investigate the associations of GLP-1RAs. To determine whether use of GLP-1RAs is associated with lower incidence of cirrhosis and its complications in this patient population, Kanwal and colleagues conducted a retrospective study, using the national Veterans Health Administration Corporate Data Warehouse and Central Cancer Registry

GLP-1 receptor agonists are peptide-based biologics that are absorbed directly into the systemic circulation from subcutaneous tissue, making them independent of intestinal absorption processes that might be affected by altered bile flow

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