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In conjunction with a reduced calorie diet and exercise, any of these GLP-1s can serve as a powerful tool to help you achieve your weight loss goals

When Side Effects Occur What to Do GI intolerance Hold dose escalation Step back to previous dose Small frequent meals Persistent vomiting Stop drug temporarily Hydrate Check renal function Suspected pancreatitis Severe epigastric pain STOP immediately Check amylase / lipase Evaluate urgently Final Clinical Takeaways Expect meaningful weight loss in the right patient, but not every patient loses equally Avoid DPP-4 inhibitors alongside semaglutide Switching from tirzepatide to semaglutide should be cautious

If nausea is severe, your prescriber may recommend anti-emetic medication in the short term

They want to know where they are in the week, when symptoms tend to show up, whether they are eating and drinking enough, and how each new dose compares with the last one