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In other work, using virtual screening against a molecular model of GCGR, de Graaf et al

Over time, this can reduce thyroid hormone production, leading to hypothyroidism and symptoms such as weight gain, fatigue, sensitivity to cold and a slower metabolism

Conflict of interest statement Within the last 36 months, FK has served on scientific advisory panels and/or been part of speaker's bureaus for, served as a consultant to and/or received research support from Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Gubra, MedImmune, MSD/Merck, Mundipharma, Norgine, Novo Nordisk, Sanofi and Zealand Pharma

Within this context, Lillys meticulous R&D strategy and market execution have paid off: Mounjaro and ZepBound are generating record sales, and Lillys pipeline is deep with next-generation incretin candidates