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Notably, metformin can directly upregulate GLP-1R expression in pancreatic cells 29,30,31
doi: 10.1136/jnnp.54.5.388 17
Enteroendocrine cells (EECs), specialized neuroendocrine cells of the intestinal epithelium, mediate this postprandial gut feedback, as they sense the luminal milieu and release gut peptides that influence metabolic homeostasis, such as GLP-1 and cholecystokinin (CCK) 16
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