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While originally developed to regulate blood sugar, these medications are now FDA-approved for weight management in certain individuals with obesity or those who are overweight with related health conditions such as type 2 diabetes or high blood pressure

This recommendation is primarily based on rodent studies demonstrating increased calcitonin secretion and C-cell hyperplasia, although only minimal GLP-1 receptor expression has been reported in human C-cells [94]

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Additionally, GLP-1 receptor activation improves insulin secretion and decreases glucagon secretion in a glucose-dependent manner, helping to stabilize blood sugar levels