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Any injection site reaction that persists beyond one week or progressively worsens should also prompt clinical evaluation to ensure appropriate management and rule out alternative diagnoses

GLP-1 receptors in the gastrointestinal tract are present at higher density than hypothalamic satiety receptors, meaning gut-related nausea appears at lower doses than appetite suppression

Assess for other causes : Your doctor may wish to investigate other potential explanations for low mood, such as thyroid function, vitamin levels (particularly B12 and vitamin D), anaemia, or other factors that can occur with significant weight loss

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