is wegovy a glp 1 Novo's becomes first GLP-1 drug approved for MASH FDA approves Wegovy pill and

Addiction 106, 12081212

doi: 10.1016/S0140-6736(64)90011-X 6 BaggioLLDruckerDJ

Preclinical studies suggest that GLP-1 receptor activation can reduce inflammatory cytokine production and modulate immune responses in ways that could be protective against infection

1519,21 The REWIND trial (Researching Cardiovascular Events With a Weekly Incretin in Diabetes) 15 reported statistically significant reductions in major adverse cardiovascular events (relative risk reduction 12%, with a number needed to treat [NNT] of 323, ie, the number of patients who would need to be treated for 1 year to prevent 1 event) and nonfatal stroke (relative risk reduction 24%, NNT 588) in patients who received dulaglutide 1.5 mg once a week compared with placebo